Life Science Research

High-tech sterile filtration, separation and purification products for genomic, proteomic and cellular research

Streamline sample prep, ensure sterility and expedite analysis in life science research laboratory workflows

 

Innovative and time-saving products for filtration, separation, and sample preparation help to streamline life science research laboratory workflows and ensure sterility from gene editing, through cell culture, to omics analysis. Solutions are available in scalable systems, reducing the risk of changes to materials during scale-up to commercial manufacturing.

 

To reduce drug discovery and development costs, there is pressure on life science researchers to rapidly move through the early stages of biotherapeutic discovery and biotherapeutic candidate selection. Key to driving efficiency is to quickly generate and select clonal cell lines that deliver high concentrations of quality recombinant protein, while screening out clone candidates that may fail in process scale-up as early as possible.

 

At Pall, we offer laboratory solutions to support researchers throughout the cell line development and clone selection process. High-performance proprietary membranes and innovative centrifugal devices address the challenges of DNA/RNA and protein sample preparation. Our high-tech filtration systems are designed to maintain sterility while streamlining harvest, clarification, and purification of cell culture products for analysis; reducing the risk of lost batches, or the frustration and cost of inconsistent results due to contamination. 

Literature Library

Cell Line Development

Pall offers solutions to support researchers throughout the cell line development process. High performance proprietary membranes address the challenges of complex next generation biologics, while supporting scale-up to commercial manufacturing processes. Innovative and time-saving products for filtration, separation, and sample preparation help streamline workflows and ensure sterility from gene editing, through cell culture, to omics analysis.

Clone Selection, Optimization and Recombinant Protein Analysis

Clone selection and optimization requires repeated analysis to identify clonal cell lines and cell culture variables that stably produce the highest titer protein expression. The goal of this stage in the drug development process is to further refine the choice of clone candidates and express proteins with the Critical Quality Attributes (CQA) of an effective protein-based drug.

DNA and RNA Purification

The advent of next generation sequencing techniques has enabled collection of unprecedented amounts of sequencing data in short spans of time. This has greatly contributed to our understanding of genomic and gene structure across many species and has also allowed us to gain much information about candidate genes for genetic disorders, cancer causing somatic mutations and misexpression due to epigenetic changes.

Protein Sample Prep & Detection

Filtration, analysis, and purification in preparing and detecting proteins presents tremendous challenges. From the discovery and development stages of new drugs, through production and delivery of therapies, Pall Life Sciences provides dependable, high-performance products that expedite and simplify your processes. We have committed ourselves to providing many sample preparation and detection tools used in basic research and proteomics.

Sterile Filtration & Clarification

Reduce filtration time, increase throughput, reduce the need for multiple filter changes and save in overall filtration costs. We manufacture membranes that are used to sterilize liquid reagents, remove particulate contamination and clarify solutions prior to further processing. These products are optimized for biological, pharmaceutical, and sterilizing filtration requirements, and exhibit superior performance compared to competitive filter devices.

Tangential Flow Filtration

Ultrafiltration preserves biological activity and saves time - Protein purification technology has progressed from methods as diverse as chemical precipitation for sample concentration or dialysis for buffer exchange towards pressure-driven purification cross flow systems utilizing ultrafiltration membranes. Ultrafiltration (UF) techniques rely on the use of polymeric membranes with highly defined pore sizes to separate molecules according to size.