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Laboratory sterile filtration and clarification techniques are critical in reducing potential contamination. We provide effective filtration sterilization and clarification solutions for global laboratory industries.
Pall Laboratory filters reduce filtration time, increase throughput, reduce the need for multiple filter changes and save in overall filtration costs. We manufacture membranes that are used to sterilize liquid reagents, remove particulate contamination and clarify solutions prior to further processing. These products are optimized for biological, pharmaceutical and sterilizing filtration requirements, and exhibit superior performance compared to competitive filter devices. Many of these products are scalable and feature identical membranes used in GMP scale manufacturing filters offered by Pall Biotech.
All too frequently, days, weeks or, in the worst case, even months of cell culture work can be lost when bacterial, fungal, or yeast contaminants are unknowingly introduced. Unfortunately, the same nutrient media that is used to grow cell cultures is often ideal for promoting the growth of these contaminants, which can quickly ruin your cultures. While there is no substitute for aseptic technique, sterilization of liquids used during cell culture assures you that media and reagents are not a source of contaminants. Heat sterilization (autoclaving) is not an option for many liquids as autoclaving may destroy critical cell culture media components and biomolecules needed for normal cell growth. Sterile filtration, therefore, is the method of choice for sterilizing cell culture media and additives. Filters capable of ambient sterilization are also useful for the general clarification and purification of cellular broths and lysates as a means to enhance the recovery of target biomolecules.
We manufacture membranes that are used to sterilize liquid reagents, remove particulate contamination, and clarify solutions prior to further processing. These products are optimized for biological, pharmaceutical and sterilizing filtration requirements.
Whether you are preparing small volumes of reagents, individual bottles of buffers or media, or developing pharmaceutical processes, we have the products to optimize your sterile filtration applications. We can help you:
- Maximize product recovery
- Reduce filtration time
- Increase throughput
- Reduce the need for multiple filter changes
- Save in overall filtration costs
At Pall, quality and ease of use are engineered into every device. We manufacture our own membranes to ensure consistent performance from lot to lot. Examples of our stringent quality specifications include:
- Sterilization by gamma irradiation – Products with Supor® (PES), Fluorodyne® II (PVDF) and Versapor® (acrylic copolymer) membranes are presterilized by gamma irradiation to eliminate potential cytotoxic residuals associated with EtO sterilization. These presterilized devices are individually packaged for convenience.
- Biological safety – Passes United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88>.
- Non-pyrogenic – Products are tested for bacterial endotoxin using the Limulus Amoebocyte Lysate (LAL) test to ensure safety.
- Low extractables – Products are optimized to reduce extractables, ensuring that unwanted materials are not introduced into filtered liquids.
We offer a range of different devices to match your filtration requirements, throughput and volumes:
Syringe filters rapidly filter small volume samples and are available with diameters of 13, 25, 32, or 37 mm. The Acrodisc sterile syringe filters are available with Supor (PES sterile filter) membrane featuring both a large EFA and PF (Pre Filter) to maximize throughput and flow rate for sterile filtration and clarification requirements.
Bottle-top Vacuum Filters
The sterile VacuCap® and VacuCap PF (Pre Filter) bottle-top filter was engineered for media preparation for cell culture applications. VacuCap PF devices, designed with a built-in prefilter, increase throughput performance with serum-containing media or other viscous solutions.
Filter capsules are suited for both prefiltration and sterile capsule applications. Capsules are available with a variety of membranes to remove particulate contamination, clarify solutions and sterilize liquid solutions prior to further processing. SupracapTM Depth Filter capsules are ideal for cellular, cell debris and general protein solution clarification as an alternative to centrifugation before sterile filtration through AcroPakTM filter capsules which are available with Supor(R) (PES) and Fluorodyne II (PVDF) membrane and offer both large EFA (Effective Filtration Area) and PF (Pre Filter) to maximise throughput and flow rate.
Filter Holders and Membranes
Membranes are used to sterilize liquid reagents, remove particulate contamination, and clarify solutions prior to further processing. These products are optimized for biological, pharmaceutical and sterilizing filtration requirements.
Reuseable filter holders with separate membrane disc filters can provide the necessary flexibility for researchers to demonstrate proof-of-concept or conduct filterability trials before investing time and effort into more costly options.
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For more information about our range of products, explore our product catalog.